research-abstracts.page.titleprefix
Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoidrich extract of Eurycoma longifolia Jack in Sprague–Dawley Rats
Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoidrich extract of Eurycoma longifolia Jack in Sprague–Dawley Rats
| dc.contributor.author | Low, Bin-Seng | |
| dc.contributor.author | Das, Prashanta Kumar | |
| dc.contributor.author | Chan, Kit-Lam | |
| dc.date.accessioned | 2022-11-10T19:11:49Z | |
| dc.date.available | 2022-11-10T19:11:49Z | |
| dc.date.copyright | Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated | |
| dc.date.issued | 2013-00-00 | |
| dc.description | Abstract: The roots of Eurycoma longifolia Jack are popularly sought as herbal medicinal supplements to improve libido and general health amongst the local ethnic population. The major quassinoids of E. longifolia improved spermatogenesis and fertility but toxicity studies have not been well documented. The reproductive toxicity, two generation of foetus teratology and the up-and-down acute toxicity were investigated in Sprague–Dawley rats orally treated with quassinoidrich E. longifolia extract (TAF273). The results showed that the median lethal dose (LD) of TAF273 for female and male rats was 1293 and >2000 mg/kg, respectively. Fertility index and litter size of the TAF273 treated were significantly 50 increased when compared with those of the non-treated animals. The TAF273-treated dams decreased in percentage of pre-implantation loss, post-implantation loss and late resorption. No toxic symptoms were observed on the TAF273treated pregnant female rats and their foetuses were normal. The no-observed adverse effect level (NOAEL) obtained from reproductive toxicity and teratology studies of TAF273 in rats was 100 mg/kg body weight/day, being more than 10-fold lower than the LD value. Thus, any human dose derived from converting the rat doses of 100 mg/kg and below may be considered as safe for further clinical studies. | |
| dc.description | Full text access : Research & development Centre, Taylor’s University, Malaysia (e-mail: GTDLSRnD@taylors.edu.my) | |
| dc.identifier.uri | https://irepo.taylors.edu.my/handle/123456789/488 | |
| dc.subject | Acute toxicity testing | |
| dc.subject | Reproductive toxicology | |
| dc.subject | Teratology | |
| dc.title | Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoidrich extract of Eurycoma longifolia Jack in Sprague–Dawley Rats | |
| dspace.entity.type | Research-Abstracts | |
| local.identifiers | vital:644 | |
| local.identifiers | valet-20140409-080829 | |
| local.language | English | |
| local.school | School of Medicine |