Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoidrich extract of Eurycoma longifolia Jack in Sprague–Dawley Rats
Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoidrich extract of Eurycoma longifolia Jack in Sprague–Dawley Rats
No Thumbnail Available
Date
2013-00-00
Authors
Low, Bin-Seng
Das, Prashanta Kumar
Chan, Kit-Lam
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Description
Abstract: The roots of Eurycoma longifolia Jack are popularly sought as herbal medicinal supplements to improve libido and general health amongst the local ethnic population. The major quassinoids of E. longifolia improved spermatogenesis and fertility but toxicity studies have not been well documented. The reproductive toxicity, two generation of foetus teratology and the up-and-down acute toxicity were investigated in Sprague–Dawley rats orally treated with quassinoidrich E. longifolia extract (TAF273). The results showed that the median lethal dose (LD) of TAF273 for female and male rats was 1293 and >2000 mg/kg, respectively. Fertility index and litter size of the TAF273 treated were significantly 50 increased when compared with those of the non-treated animals. The TAF273-treated dams decreased in percentage of pre-implantation loss, post-implantation loss and late resorption. No toxic symptoms were observed on the TAF273treated pregnant female rats and their foetuses were normal. The no-observed adverse effect level (NOAEL) obtained from reproductive toxicity and teratology studies of TAF273 in rats was 100 mg/kg body weight/day, being more than 10-fold lower than the LD value. Thus, any human dose derived from converting the rat doses of 100 mg/kg and below may be considered as safe for further clinical studies.
Full text access : Research & development Centre, Taylor’s University, Malaysia (e-mail: GTDLSRnD@taylors.edu.my)
Full text access : Research & development Centre, Taylor’s University, Malaysia (e-mail: GTDLSRnD@taylors.edu.my)
Title
Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoidrich extract of Eurycoma longifolia Jack in Sprague–Dawley Rats
Author's Name
Author(s) Name
Author(s)(Original)
Low, Bin-Seng
Das, Prashanta Kumar
Chan, Kit-Lam
Das, Prashanta Kumar
Chan, Kit-Lam
Editor(s)(Original)
Recipient
Creator(s) Name
Date
Year Created
2013-00-00
Description
Abstract: The roots of Eurycoma longifolia Jack are popularly sought as herbal medicinal supplements to improve libido and general health amongst the local ethnic population. The major quassinoids of E. longifolia improved spermatogenesis and fertility but toxicity studies have not been well documented. The reproductive toxicity, two generation of foetus teratology and the up-and-down acute toxicity were investigated in Sprague–Dawley rats orally treated with quassinoidrich E. longifolia extract (TAF273). The results showed that the median lethal dose (LD) of TAF273 for female and male rats was 1293 and >2000 mg/kg, respectively. Fertility index and litter size of the TAF273 treated were significantly 50 increased when compared with those of the non-treated animals. The TAF273-treated dams decreased in percentage of pre-implantation loss, post-implantation loss and late resorption. No toxic symptoms were observed on the TAF273treated pregnant female rats and their foetuses were normal. The no-observed adverse effect level (NOAEL) obtained from reproductive toxicity and teratology studies of TAF273 in rats was 100 mg/kg body weight/day, being more than 10-fold lower than the LD value. Thus, any human dose derived from converting the rat doses of 100 mg/kg and below may be considered as safe for further clinical studies.
Full text access : Research & development Centre, Taylor’s University, Malaysia (e-mail: GTDLSRnD@taylors.edu.my)
Full text access : Research & development Centre, Taylor’s University, Malaysia (e-mail: GTDLSRnD@taylors.edu.my)
Running Time
Recording Format
Citation
Subject
Acute toxicity testing
Reproductive toxicology
Teratology
Reproductive toxicology
Teratology
Subject (Others)
Dissertation Advisor
Chapter Number
Phone contacts
Content
Degree Name
Medium
Newspaper Name
Notes
Total Pages
Patent Number
Title of Proceedings
Academic Qualifications
Research Field/Interest
School
School of Medicine