research-abstracts.page.titleprefix
2-Methoxy-1,4-Naphthoquinone (MNQ) suppresses the invasion and migration of a human metastatic breast cancer cell line (MDA-MB-231)
2-Methoxy-1,4-Naphthoquinone (MNQ) suppresses the invasion and migration of a human metastatic breast cancer cell line (MDA-MB-231)
| dc.contributor.author | Liew, Kitson | |
| dc.contributor.author | Voon, Phelim Chen Yong | |
| dc.contributor.author | Yang, Mooi Lim | |
| dc.contributor.author | Visweswaran Navaratnam | |
| dc.contributor.author | Siong, Anthony Hock Ho | |
| dc.date.accessioned | 2022-11-10T19:11:42Z | |
| dc.date.available | 2022-11-10T19:11:42Z | |
| dc.date.copyright | Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated | |
| dc.date.issued | 28/11/2013 | |
| dc.description | Abstract : Metastasis contributes to the escalating mortality rate among cancer patients worldwide. The search for novel and more effective anti-metastatic agent is crucial owing to the lack of anticancer drugs that can successfully combat metastasis. Hence, this study aims to examine the effects of 2-Methoxy-1,4-Naphthoquinone (MNQ) towards the metastasis of MDA-MB-231 cells. In invasion assays, the number of cells permeating across a Matrigel barrier was found to be decreased in a dose-dependent manner upon treatment with MNQ (0–7.5 uM). In wound-healing migration assays, MNQ exhibited dose-dependent inhibi- tion of cell migration in which significant reduction in the zone of closure was observed as compared to untreated controls. Furthermore, the proteolytic activity of a pivotal metastatic mediator, matrix metalloproteinase-9 (MMP-9) was also downregulated by MNQ as determined by gelatin zymography. This study reports for the first time, the ability of MNQ to inhibit the invasion and migration characteristics of a highly metastatic MDA-MB-231 cancer cell line. | |
| dc.description | Full text access : Research & development Centre, Taylor’s University, Malaysia (e-mail: GTDLSRnD@taylors.edu.my) | |
| dc.identifier.uri | https://irepo.taylors.edu.my/handle/123456789/483 | |
| dc.subject | Metastasis | |
| dc.subject | Cancer invasiveness | |
| dc.subject | Metalloproteinases | |
| dc.title | 2-Methoxy-1,4-Naphthoquinone (MNQ) suppresses the invasion and migration of a human metastatic breast cancer cell line (MDA-MB-231) | |
| dspace.entity.type | Research-Abstracts | |
| local.identifiers | vital:577 | |
| local.identifiers | valet-20140318-154252 | |
| local.language | English | |
| local.school | School of Biosciences |